"Forty two?!" yelled Loonquawl. "Is that all you've got to show for seven and a half million years' work?"
"I checked it very thoroughly," said the computer, "and that quite definitely is the answer. I think the problem, to be quite honest with you, is that you've never actually known what the question is."
From trusty Wikipedia (which sounds like a character from Adams but isn't) I learn that Adams created a puzzle for his cover picture of forty two colored balls (above), which, however, nobody noticed was a puzzle. "Everybody was looking for hidden meanings and puzzles and significances in what I had written (like 'is it significant that 6 * 9 is 42 in base 13?'. As if.) So I thought that just for a change I would actually construct a puzzle and see how many people solved it. Of course, nobody paid it any attention. I think that's terribly significant."